References

  1. N. L. Andrews, K. A. Lidke, J. R. Pfeiffer, A. R. Burns & B. S. Wilson (2008): Actin restricts FCeRI diffusion and facilitates antigen-induced receptor immobilization. Nat Cell Biol 10, pp. 955–963, doi:10.1038/ncb1755.
  2. D. A. Birk, J. Barbato, L. Mureebe & R. A. Chaer (2010): Current insights on the biology and clinical aspects of VEGF regulation. Vasc Endovascular Surg 42, pp. 517–530, doi:10.1177/1538574408322755.
  3. M. N. Costa, K. Radhakrishnan, B. S. Wilson, D. G. Vlachos & J. S. Edwards (2009): Coupled Stochastic Spatial and Non-Spatial Simulations of ErbB1 Signaling Pathways Demonstrate the Importance of Spatial Organization on Signal Transduction. PLOS One 4(7), pp. 6316, doi:10.1371/journal.pone.0006316.s001.
  4. N. Ferrara, K. J. Hilla, H. P. Gerber & W. Novotny (2004): Discovery anddevelopment of bevazicumab, an anti-VEGF antibody for treating cancer. Net Rev Drug Discov 3, pp. 391–400, doi:10.1038/nrd1381.
  5. F. Mac Gabhann & A. S. Popel (2007): Dimerization of VEGF receptors and implications for signal transduction: A computational study. Biophysical Chemistry 128, pp. 125–139, doi:10.1016/j.bpc.2007.03.010.
  6. A. M. Gallegos, S. M. Storey, A. B. Kier, F. Shroeder & J. M. Ball (2006): Structure and cholesterol dynamics of caveloae/raft and nonraft plasma membrane domains. Biochemistry 45, pp. 12100–12116, doi:10.1021/bi0602720.
  7. Á. M. Halász, H.-J. Lai, M. M. McCabe Pryor, K. Radhakrishnan & J. S. Edwards (2013): Analytical Solution of Steady State Equations for Chemical Reaction Networks with Bilinear Rate Laws. IEEE/ACM Transactions on Computational Biology and Bioinformatics, doi:10.1109/TCBB.2013.41. Epub before print.
  8. D. Hanahan & J. Folkman (1996): Patterns and emerging mechanisms of the angiogenetic switch during tumorigenesis. Cell 86, pp. 353–364, doi:10.1016/S0092-8674(00)80108-7.
  9. M.-Y. Hsieh, S. Yang, M. Raymond-Stinz, S. Steinberg, D. Vlachos, W. Shu, B. Wilson & J. S. Edwards (2008): Stochastic Simulations of ErbB Homo- and Hetero-Dimerization: Potential IMpacts of Receptor Conformational State and Spatial Segregation. IET Systems Biology 2, pp. 256–272, doi:10.1049/iet-syb:20070073.
  10. A. F. Karamysheva (2008): Mechanisms of angiogenesis. Biochemistry (Mosc) 73, pp. 751–762, doi:10.1134/S0006297908070031.
  11. L. B. Kleiman, T. Maiwald, H. Conzelman, D. A. Lauffenburger & P. K. Sorger (2011): Rapid phospho-turnover by receptor tyrosine kinases impacts downstream signaling and drug binding. Molecular Cell 43, pp. 723ĘC737, doi:10.1016/j.molcel.2011.07.014.
  12. M. A. Lemon & J. Schlessinger (2010): Cell Signaling by Receptor Tyrosine Kinases. Cell 141, pp. 1117–1134, doi:10.1016/j.cell.2010.06.011.
  13. B. F. Lillemeier, J. R. Pfeiffer, Z. Surviladze, B. S. Wilson & M. M. Davis (2006): Plasma membrane-associated proteins are clustered into islands attached to the cytoskeleton. Proc Natl Acad Sci USA 103, pp. 18992–18997, doi:10.1073/pnas.0609009103.
  14. M. Lohela, M. Bry, T. Tammela & K. Alitalo (2009): VEGFs and receptors involved in angiogenesis versus lymphangiogenesis. Curr Opin Cell Biol 21, pp. 154–165, doi:10.1016/j.ceb.2008.12.012.
  15. K. Mayawala, D. G. Vlachos & J. S. Edwards (2005): Computational modeling reveals molecular details of epidermal growth factor binding. BMC Cell Biol 6, pp. 41, doi:10.1186/1471-2121-6-41.
  16. K. Mayawala, D. G. Vlachos & J. S. Edwards (2005): Heterogeneities in EGF rceptor density at the cell surface can lead to concave up Scatchard plot of EGF binding. FEBS Letters 579, pp. 3043–3047, doi:10.1016/j.febslet.2005.04.059.
  17. H. Ming-Yu, S. Yang, M. A. Raymond-Stinz, J. S. Edwards & B. S. Wilson (2010): Spatiotemporal modeling of signalingprotein recruitment to EGFR. BMC Systems Biology 4, pp. 57.
  18. K. Murase, T. Fujiwara, Y. Umemura, K. Suzuki, R. Iino & H. Murakoshi (2004): Ultrafine membrane compartments for molecular diffusion as revealed by single molecule techniques. Biophys J 75, pp. 4075–4093, doi:10.1529/biophysj.103.035717.
  19. D. A. Olsson, J. Kreuger & L. Claesson-Welsh (2006): VEGF receptor signaling - in control of vascular function. Nat Rev Mol Cell Biol 7, pp. 359–371, doi:10.1038/nrm1911.
  20. G. Orr, D. Hu, S. Ozcelik, L. K. Opresko & H. S. Wiley (2005): Cholesterol dictates the freedom of EGF receptors and HER2 in the plane of the membrane. Biophys J 89, pp. 1362–1373, doi:10.1529/biophysj.104.056192.
  21. J. Plouet, J. Schilling & D. Gospodarowicz (1989): Isolation and characterization of a newly identified endothelial cell mitogen produced by AtT-20 cels. EMBO J 8, pp. 3801–3806.
  22. K. Ritchie & A. Kusumi (2003): Single-particle tracking image microscopy. Methods Enzymol 360, pp. 618–634, doi:10.1016/S0076-6879(03)60131-X.
  23. R. J. Roskoski (2008): VEGF receptor protein-tyrosine kinases: structure and regulation. Biochem Biophys Res Commun 375, pp. 287–291, doi:10.1016/j.bbrc.2008.07.121.
  24. F. Schoreder, A. M. Gallegos, B. P. Atshaves, S. M. Storey & A. L. McIntosh (2001): Recent advances in membrane microdomains: rafts, caveolae, and intracellular cholesterol trafficking. Exp Bio9l Med (Maywood) 226, pp. 873–890.
  25. D. R. Senger, S. J. Galli, A. M. Dvorak, C. A. Perruzzi, V. S. Harvey & H. F. Dvorak (1983): Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 219, pp. 983–985, doi:10.1126/science.6823562.
  26. S. J. Singer & G. L. Nicholson (1972): The Fluid Mosaic Model of the Structure of Cell Membranes. Science 175, pp. 720–731, doi:10.1126/science.175.4023.720.
  27. E. Stuttfield & K. Ballmer-Hofer (2009): Structure and Function of VEGF Receptors. IUBMB Life 61(9), pp. 915–922, doi:10.1002/iub.234.
  28. G. Vereb, J. Szollosi, J. Matko, P. Nagy, T. Farkas, L. Vigh, L. Matyus, T. A. Waldmann & S. Djanovich (2003): Dynamic, yet structured: The cell membrane threedecades after the Singer-Nicolson model. Proc Natl Acad Sci USA 100(14), pp. 8053–8058, doi:10.1073/pnas.1332550100.
  29. B. S. Wilson, J. R. Pfeiffer, M. A. Raymond-Stintz, D. Lidke & N. Andrews (2007): Exploring membrane domains using native membrane sheets and transmission electron microscopy. Methods Mol Biol 398, pp. 245–261, doi:10.1007/978-1-59745-513-8_17.
  30. S. Yang, M. A. Raymond-Stinz, W. Ying, J. Zhang, D. S. Lidke, S. L. Steinberg, L. Williams, J. M. Oliver & B. S. Wilson (2007): Mapping ErbB rceptors on breast cancer cell membranes during signal transduction. J Cell Sci 120, pp. 2763–2773, doi:10.1242/jcs.007658.

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