A Model of Colonic Crypts using SBML Spatial

Daniele Ramazzotti
(Università degli Studi di Milano-Bicocca)
Carlo Maj
(Università degli Studi di Milano-Bicocca)
Marco Antoniotti
(Università degli Studi di Milano-Bicocca)

The Spatial Processes package enables an explicit definition of a spatial environment on top of the normal dynamic modeling SBML capabilities. The possibility of an explicit representation of spatial dynamics increases the representation power of SBML. In this work we used those new SBML features to define an extensive model of colonic crypts composed of the main cellular types (from stem cells to fully differentiated cells), alongside their spatial dynamics.

In Alex Graudenzi, Giulio Caravagna, Giancarlo Mauri and Marco Antoniotti: Proceedings Wivace 2013 - Italian Workshop on Artificial Life and Evolutionary Computation (Wivace 2013), Milan, Italy, July 1-2, 2013, Electronic Proceedings in Theoretical Computer Science 130, pp. 74–78.
Published: 30th September 2013.

ArXived at: http://dx.doi.org/10.4204/EPTCS.130.11 bibtex PDF
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