Multiscale Bone Remodelling with Spatial P Systems

Diletta Cacciagrano
(School of Science and Technology - University of Camerino)
Flavio Corradini
(School of Science and Technology - University of Camerino)
Emanuela Merelli
(School of Science and Technology - University of Camerino)
Luca Tesei
(School of Science and Technology - University of Camerino)

Many biological phenomena are inherently multiscale, i.e. they are characterized by interactions involving different spatial and temporal scales simultaneously. Though several approaches have been proposed to provide "multilayer" models, only Complex Automata, derived from Cellular Automata, naturally embed spatial information and realize multiscaling with well-established inter-scale integration schemas. Spatial P systems, a variant of P systems in which a more geometric concept of space has been added, have several characteristics in common with Cellular Automata. We propose such a formalism as a basis to rephrase the Complex Automata multiscaling approach and, in this perspective, provide a 2-scale Spatial P system describing bone remodelling. The proposed model not only results to be highly faithful and expressive in a multiscale scenario, but also highlights the need of a deep and formal expressiveness study involving Complex Automata, Spatial P systems and other promising multiscale approaches, such as our shape-based one already resulted to be highly faithful.

In Gabriel Ciobanu and Maciej Koutny: Proceedings Fourth Workshop on Membrane Computing and Biologically Inspired Process Calculi 2010 (MeCBIC 2010), Jena, Germany, 23 August 2010, Electronic Proceedings in Theoretical Computer Science 40, pp. 70–84.
Published: 30th October 2010.

ArXived at: bibtex PDF

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